We use the established, standard building block of modern microelectronics - the silicon transistor - to detect DNA as a simple on/off process.
Matching nucleotides that incorporate during DNA sequencing release hydrogen ions, which can be detected as an electrical signal. If there is no match, no hydrogen ions are released and no signal is detected. This method can be universally applied to any DNA and RNA analysis on a standard CMOS semiconductor chip.
There’s no need for fluorescent dyes or labels, or precision optics, which make current DNA analysis equipment bulky and expensive.
There’s no need for fluorescent dyes or labels, or precision optics
© 2016 DNA Electronics